What is the Origin of Anorexigenic Signals?

The term combines the Greek prefix an- meaning "without," orexis meaning "appetite," and the suffix -genic meaning "producing." This lexicon is firmly situated within the fields of neuroendocrinology and metabolic research, defining the body's internal mechanisms for appetite suppression.

What is the Mechanism of Anorexigenic Signals?

Anorexigenic signals are primarily released from the gastrointestinal tract, adipose tissue, or the central nervous system in response to nutrient intake and energy status. Key examples include Cholecystokinin (CCK), Peptide YY (PYY), and alpha-Melanocyte-Stimulating Hormone (alpha-MSH). These molecules travel via the circulation or neural pathways to the hypothalamus, specifically targeting centers like the arcuate nucleus, to suppress neuropeptide Y (NPY) activity, thereby reducing food intake.

Anorexigenic Signals

Meaning

Anorexigenic Signals are a class of physiological cues, often peptides or neurotransmitters, that are generated peripherally or centrally to promote satiety and reduce the drive to consume food. These signals act as critical components of the homeostatic system that regulates energy balance and body weight. Clinically, they are crucial for understanding and treating disorders of appetite and metabolism, offering therapeutic targets for obesity.