What is the Origin of Anorexigenic Peptides?

The term is a compound derived from Greek roots: "an-" meaning without, "orexis" meaning appetite or desire, and "genic" meaning producing. Thus, they are literally "appetite-suppressing" substances. The discovery of these peptides, such as cholecystokinin (CCK) and peptide YY (PYY), stemmed from research into the physiological control of feeding behavior and energy homeostasis.

What is the Mechanism of Anorexigenic Peptides?

These peptides are released into the bloodstream and act on specific receptors, particularly within the hypothalamus, the brain's appetite control center. For instance, Glucagon-like peptide-1 (GLP-1) and PYY are secreted post-prandially, signaling fullness to the nucleus of the solitary tract and the arcuate nucleus. This direct neurohormonal communication inhibits the orexigenic pathways, leading to a cessation of feeding behavior and contributing to long-term energy balance.

Anorexigenic Peptides ∞ Area

Anorexigenic Peptides

Meaning

Anorexigenic peptides are a class of signaling molecules, synthesized primarily in the gastrointestinal tract and brain, that function to suppress appetite and promote satiety. These hormonal messengers communicate the body’s fed state to the central nervous system, effectively reducing the desire to consume food. Maintaining a healthy balance of these peptides is critical for metabolic regulation and weight management.