What is the Origin of Anorexigenic Feedback Loop?

The term combines Greek roots: an- meaning "without," orexis meaning "appetite," and genos meaning "producing," thus describing something that "produces a lack of appetite." The concept of a "feedback loop" originates from general systems theory, applied here to endocrinology to describe the continuous, self-regulating circuit of hormonal signals.

What is the Mechanism of Anorexigenic Feedback Loop?

Following nutrient ingestion, various peripheral tissues, notably the gut and adipose tissue, release satiety hormones such as Peptide YY, Cholecystokinin, and Leptin. These gut peptide mediators and adipokines travel through the circulation to the arcuate nucleus of the hypothalamus in the brain. Upon reaching the hypothalamus, they activate Pro-opiomelanocortin (POMC) neurons, which then release anorexigenic neuropeptides like alpha-melanocyte-stimulating hormone. This central activation suppresses the orexigenic signals, resulting in a perceived reduction in hunger and the termination of a meal.

Anorexigenic Feedback Loop ∞ Area

Anorexigenic Feedback Loop

Meaning

The Anorexigenic Feedback Loop is a physiological control system that signals satiety to the central nervous system, effectively reducing the drive to consume food. This essential homeostatic mechanism helps regulate energy intake and maintain a stable body weight over the long term. A robust loop is critical for preventing excessive energy accumulation and is a key focus in clinical strategies for weight management. Impairments in this signaling pathway can contribute significantly to chronic overconsumption and metabolic dysregulation.