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Angiotensinogen Gene

Meaning

The Angiotensinogen Gene, formally designated as AGT, contains the genetic code for producing the protein angiotensinogen, which serves as the exclusive precursor molecule for the potent vasoactive hormone angiotensin II. This gene is a central, initiating component of the Renin-Angiotensin-Aldosterone System (RAAS), a critical endocrine cascade that precisely regulates systemic blood pressure, fluid volume, and electrolyte balance throughout the body. Variations, or polymorphisms, within the AGT gene can significantly alter the plasma concentration of angiotensinogen, thereby modulating an individual’s baseline cardiovascular and renal risk profile.