What is the Origin of Angiotensin IV Analogs?

The concept emerged from the discovery of Angiotensin IV's independent role in memory and learning, separate from the classical vasoconstrictive actions of Angiotensin II. Research focused on the specific receptor Angiotensin IV binds to, known as the AT4 receptor or Insulin-regulated aminopeptidase (IRAP), leading to the rational design of stable, potent analogs. This research bridges cardiovascular endocrinology with neuropharmacology.

What is the Mechanism of Angiotensin IV Analogs?

The mechanism involves the selective, high-affinity binding of the analogs to the AT4 receptor, which is densely expressed in brain regions critical for memory, such as the hippocampus. Activation of this receptor is associated with the release of neurotrophic factors and the potentiation of long-term potentiation, the cellular basis for learning and memory. This action supports improved cerebral blood flow and enhances the synaptic efficacy required for robust cognitive function.

Angiotensin IV Analogs ∞ Area

Angiotensin IV Analogs

Meaning

Angiotensin IV Analogs are synthetic peptide compounds structurally designed to mimic the naturally occurring Angiotensin IV, a heptapeptide derived from the Renin-Angiotensin System. These analogs are investigated for their therapeutic potential, primarily for their non-pressor effects on the central nervous system, distinct from the system’s role in blood pressure regulation. They are considered promising agents for cognitive enhancement and neuroprotection.