What is the Origin of Angiotensin Converting Enzyme?

The enzyme is named for its function in converting angiotensin I to angiotensin II, and its pivotal role was elucidated in the mid-20th century, quickly becoming a major pharmacological target. It belongs to the peptidase family and is widely expressed, particularly in the endothelial cells of the lungs, kidneys, and heart.

What is the Mechanism of Angiotensin Converting Enzyme?

Angiotensin Converting Enzyme (ACE) cleaves the C-terminal dipeptide from the inactive decapeptide angiotensin I, producing the active octapeptide angiotensin II. Angiotensin II then acts on specific receptors, triggering systemic vasoconstriction, aldosterone release from the adrenal cortex, and antidiuretic hormone secretion. These actions collectively elevate blood pressure and expand plasma volume; pharmacological inhibitors target this enzymatic activity to reduce systemic vascular resistance.

Angiotensin Converting Enzyme

Meaning

Angiotensin Converting Enzyme (ACE) is a critical zinc-containing dipeptidyl carboxypeptidase enzyme that plays a central role in regulating blood pressure and fluid balance within the cardiovascular system. Clinically, it is known for its function in the renin-angiotensin-aldosterone system (RAAS), a major endocrine axis. This enzyme catalyzes the conversion of an inactive precursor into a potent vasoactive peptide.