What is the Origin of Angiotensin-(1-7)?

Angiotensin-(1-7) is a product of the enzymatic cleavage of its precursor, Angiotensin I, primarily by the Angiotensin-Converting Enzyme 2 (ACE2). The discovery of ACE2 and its enzymatic product revealed a previously unrecognized arm of the classic RAS, shifting the understanding of this system from a purely pressor pathway to a balanced regulatory network. The nomenclature is derived from its sequence of amino acids cleaved from the larger angiotensinogen protein.

What is the Mechanism of Angiotensin-(1-7)?

The primary mechanism of action involves binding to and activating the Mas receptor (MasR), a G protein-coupled receptor found on various cell types, including endothelial cells and cardiomyocytes. Activation of the MasR triggers signaling pathways that promote vasodilation, inhibit cell proliferation, and exert anti-fibrotic and anti-inflammatory effects. This protective signaling contributes significantly to cardiovascular and renal health, offering a natural counterbalance to the Angiotensin II/AT1 receptor axis.

Angiotensin-(1-7) ∞ Area

Angiotensin-(1-7)

Meaning

A biologically active heptapeptide (seven amino acid peptide) that serves as a critical counter-regulatory component within the Renin-Angiotensin System (RAS). This peptide is known for its beneficial cardiovascular and metabolic effects, often opposing the vasoconstrictive and pro-inflammatory actions of Angiotensin II. It is recognized as a key mediator in maintaining vascular and renal homeostasis.