What is the Origin of Angiogenesis in Bone?

The term is derived from the Greek angeion (vessel) and genesis (creation), specifically applied to the skeletal system's necessary vasculature. Bone tissue, while appearing solid, is highly vascularized, a biological necessity recognized in physiology for centuries. The molecular mechanisms of new vessel growth and its connection to skeletal health became clear in modern research.

What is the Mechanism of Angiogenesis in Bone?

This process is tightly regulated by a complex interplay of local growth factors and systemic hormones, most notably Vascular Endothelial Growth Factor (VEGF). Osteoclasts, the bone-resorbing cells, are a primary source of VEGF, which stimulates endothelial cells to proliferate and form new capillaries. The coordinated presence of blood vessels and progenitor cells is mandatory for successful endochondral and intramembranous ossification during development and repair.

Angiogenesis in Bone ∞ Area

Angiogenesis in Bone

Meaning

Angiogenesis in bone describes the physiological process of new blood vessel formation within skeletal tissue. This vascularization is indispensable for bone development, continuous remodeling, and efficient fracture healing, as it ensures the delivery of oxygen, nutrients, and critical regulatory cells. A robust blood supply is essential for the coordinated activity of the osteoblasts and osteoclasts that govern bone matrix integrity.