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Androstanediol

Meaning

Androstanediol is a critical steroid metabolite, existing primarily as 3α-androstanediol, which represents a downstream product of the potent androgen dihydrotestosterone (DHT). Clinically, this compound serves as a valuable biomarker, reflecting the activity of androgen metabolism in peripheral tissues such as the skin and prostate. Elevated levels of 3α-androstanediol often suggest increased activity of the 5-alpha reductase enzyme, the key catalyst in converting testosterone to DHT. Monitoring this metabolite provides a more nuanced view of local androgen action than measuring circulating testosterone alone.