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Androstane Neurosteroids

Meaning

Androstane neurosteroids are a class of steroid molecules synthesized de novo within the central and peripheral nervous systems from cholesterol or peripheral steroid precursors, specifically sharing the androstane carbon skeleton. These compounds function as local regulators of neuronal excitability and synaptic transmission, acting rapidly outside of traditional genomic pathways. Dihydrotestosterone (DHT) and its metabolites are key examples, exhibiting potent effects on brain function and behavior. Their role highlights a critical link between hormonal metabolism and direct neural signaling.