Andropause describes the gradual decline in androgenic function observed in aging males, often associated with symptoms like reduced libido, fatigue, and altered body composition. Clinically, it reflects a state where circulating testosterone levels fall below optimal physiological ranges, impacting overall vitality and metabolic regulation. This process contrasts with the abrupt cessation of ovarian function seen in menopause, presenting instead as a protracted endocrine shift.
Origin
The term is a constructed analogy derived from the Greek root “andro” (man) and “pause” (cessation), intended to mirror the concept of menopause in women. Its use signifies a recognized, albeit variable, stage of male hormonal aging characterized by diminished gonadal output. This concept remains important in discussions surrounding male aging and testosterone replacement protocols.
Mechanism
The primary physiological mechanism involves a reduction in Leydig cell responsiveness to Luteinizing Hormone (LH) and a potential relative increase in Sex Hormone-Binding Globulin (SHBG) levels. This combination results in lower free testosterone bio-availability, which impairs the normal signaling cascade mediated by the Androgen Receptor in target tissues. Consequently, tissues dependent on robust androgenic stimulation experience functional decline.
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