Andropause Treatment refers to the clinical management of symptoms associated with age-related decline in circulating androgen levels in men, often referred to more precisely as late-onset hypogonadism. The goal of this therapeutic strategy is to alleviate clinically significant symptoms such as decreased libido, fatigue, mood disturbances, and loss of muscle mass. Treatment is always preceded by comprehensive diagnostic testing to confirm a genuine biochemical deficiency correlating with the patient’s presentation.
Origin
The concept arose from recognizing a constellation of symptoms in aging men paralleling the female menopausal transition, hence the popular but less scientifically rigorous term ‘andropause.’ Clinical treatment protocols are derived from established endocrinology guidelines for managing hypogonadism. The clinical approach is founded on the principle of hormonal replacement to restore physiological function.
Mechanism
The primary mechanism of Andropause Treatment is Testosterone Replacement Therapy (TRT), which involves administering exogenous testosterone via various routes like injections, gels, or pellets. This intervention raises serum testosterone concentrations to a level within the optimal physiological range. By activating the Androgen Receptor (AR) systemically, TRT aims to reverse the catabolic state, improve bone mineral density, enhance mood, and restore sexual function.
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