What is the Origin of Andropause Symptoms?

The term 'Andropause' is a compound word derived from the Greek roots andro meaning 'man' and pausis meaning 'cessation,' intended to draw an analogy to female menopause. While the term is widely used, the clinical decline in men is generally more gradual than the abrupt cessation seen in women, leading to the preference for more precise clinical terminology. The concept gained clinical traction in the mid-20th century as endocrinology began to systematically explore age-related hormonal shifts in the male population.

What is the Mechanism of Andropause Symptoms?

The symptoms are a direct consequence of reduced androgen receptor activation throughout the body, driven by the age-related decrease in testicular testosterone production and often an increase in Sex Hormone Binding Globulin (SHBG). This hormonal deficit affects target tissues in the central nervous system, musculoskeletal system, and vascular endothelium. Decreased androgenic signaling alters neurotransmitter balance, impairs the anabolic drive for protein synthesis in muscle and bone, and can compromise endothelial function, leading to the observable clinical syndrome.

Andropause Symptoms

Meaning

Andropause Symptoms refer to the collection of clinical manifestations experienced by some men, typically associated with a gradual, age-related decline in bioavailable testosterone and other androgen levels. This syndrome is often clinically termed Late-Onset Hypogonadism (LOH) or Age-Related Testosterone Deficiency, reflecting the subtle but progressive nature of the hormonal shift. Common presentations include changes in sexual function, such as reduced libido and erectile quality, alongside mood disturbances, decreased muscle mass, and reduced bone density. The recognition of these symptoms necessitates a thorough endocrine evaluation to confirm the underlying hormonal deficit and guide appropriate intervention.