What is the Origin of Andropause Skin Changes?

The term combines "andropause," derived from the Greek andro (man) and pausis (cessation), and "skin changes," referring to the resulting cutaneous modifications. This concept is rooted in endocrinology and gerontology, linking systemic hormonal shifts to specific organ system deterioration. It is a physiological descriptor within the continuum of male aging and hormonal regulation.

What is the Mechanism of Andropause Skin Changes?

Reduced circulating testosterone diminishes its signaling through dermal androgen receptors, which are crucial for fibroblast activity and collagen synthesis. This decline in anabolic signaling leads to a net catabolic state within the dermal matrix, reducing the production of structural proteins like collagen and elastin. Furthermore, the decrease in androgen-dependent sebum production compromises the skin's barrier function, contributing to xerosis and increased trans-epidermal water loss.

Andropause Skin Changes ∞ Area

Andropause Skin Changes

Meaning

The dermatological and structural alterations observed in men corresponding to the age-related decline in androgen levels, specifically testosterone, a condition clinically termed andropause or late-onset hypogonadism. These changes manifest as a progressive thinning of the epidermis and dermis, diminished collagen density, and reduced elasticity. Clinically, this hormonal shift contributes to increased skin fragility, impaired wound healing capacity, and a reduction in sebaceous gland activity leading to dryness.