What is the Origin of Andropause Hormonal Effects?

The term "andropause" is derived from the Greek words andro (male) and pausis (cessation), conceptually mirroring menopause, although the decline is typically more gradual. The clinical understanding of its hormonal effects stems from endocrinology research focused on the hypothalamic-pituitary-gonadal (HPG) axis dysregulation over the lifespan. This framework helps classify the observed symptoms as a direct consequence of insufficient circulating androgens.

What is the Mechanism of Andropause Hormonal Effects?

Declining Leydig cell function in the testes leads to reduced testosterone synthesis, while simultaneously, an increase in Sex Hormone-Binding Globulin (SHBG) further lowers the bioavailable free testosterone fraction. This hormonal insufficiency affects androgen receptor signaling across target tissues, including muscle, bone, brain, and adipose tissue. The altered signaling drives catabolic changes, bone density loss, shifts in body composition, and neuroendocrine disruptions contributing to symptoms like fatigue and mood changes.

Andropause Hormonal Effects ∞ Area

Andropause Hormonal Effects

Meaning

The clinical and physiological consequences arising from the gradual, age-related decline in androgen levels, primarily testosterone, in aging males. These effects represent a spectrum of systemic changes, influencing metabolic, psychological, and physical well-being. This hormonal shift is a key aspect of male reproductive aging, distinct from the abrupt cessation seen in female menopause. The resulting low testosterone state, often termed late-onset hypogonadism, can significantly impact quality of life and long-term health markers.