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AndrogenTherapy

Meaning

The administration of androgens (male sex hormones) to supplement or replace endogenous production. It operates within the endocrine system, influencing male sexual characteristics, muscle mass, bone density, and mood. It’s relevant in conditions of androgen deficiency or specific therapeutic goals. Clinically important for managing hypogonadism in men, treating certain types of anemia, and in hormone replacement therapy. It can significantly impact quality of life by addressing symptoms of low testosterone. Androgens bind to intracellular androgen receptors, forming complexes that translocate to the nucleus and modulate gene expression, affecting protein synthesis and cellular function. This leads to effects on target tissues like muscle, bone, prostate, and brain. Prescribed for diagnosed androgen deficiency, often administered via injections, transdermal patches, gels, or oral formulations. Its use requires careful consideration of individual patient needs and potential risks. Monitored through serum testosterone levels (total and free), LH, FSH, PSA (prostate-specific antigen), hematocrit, and clinical assessment of symptoms such as libido, energy, and mood. Potential risks include polycythemia, acne, male pattern baldness, fluid retention, sleep apnea exacerbation, mood disturbances, and potential cardiovascular events. In women, it can cause virilization. It is contraindicated in men with prostate or breast cancer.