Clinical strategies aimed at maintaining or optimizing the functional levels of endogenous androgens, such as testosterone and DHEA, within physiological reference ranges for the individual. This support is crucial for preserving lean mass, bone density, and maintaining appropriate libido and energy substrates. We address this to ensure robust anabolic signaling across target tissues.
Origin
The term originates from the Greek ‘andros’ (man) and ‘genes’ (producing), referring to hormones that drive male characteristics, though androgens are vital for all sexes. In a clinical context, ‘support’ implies an intervention, nutritional or pharmacological, designed to promote the synthesis or effective action of these steroids. It speaks to the foundational role of these hormones in metabolic balance.
Mechanism
Androgenic support functions primarily by ensuring adequate substrate availability for the HPG axis and supporting the downstream binding of androgens to the intracellular androgen receptor. Optimal support mitigates the negative effects of catabolic states, promoting protein synthesis pathways via the mTOR signaling cascade. This action directly influences muscle protein accretion and efficient substrate utilization during periods of high demand.
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