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Androgenic Signaling Pathways

Meaning

These are the complex intracellular communication cascades initiated by the binding of androgen hormones, such as testosterone and dihydrotestosterone (DHT), to the androgen receptor (AR). The pathways mediate the physiological effects of androgens, which are essential for the development and maintenance of male secondary sexual characteristics, muscle mass, bone density, and libido in both sexes. Dysregulation in these signaling pathways can lead to conditions like androgen insensitivity syndrome or contribute to hyperandrogenic states.