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Androgenic Receptor Upregulation

Meaning

Androgenic Receptor Upregulation signifies an increased density or heightened sensitivity of androgen receptors on target cells throughout the body. This molecular event enhances the cell’s capacity to receive and respond to circulating androgens, such as testosterone and dihydrotestosterone (DHT). Clinically, this mechanism is crucial as it can amplify the biological effects of these hormones, even when their serum concentrations remain within a stable range. It fundamentally represents a key adaptive strategy in maintaining robust hormonal signaling within tissues.