What is the Origin of Androgenic Decline?

The term derives from the Greek andrós, meaning "of a man," and gennán, meaning "to produce," referring to male-producing hormones, combined with the Latin declinare, meaning "to bend down" or "sink." Clinically, it is a key component of conditions like late-onset hypogonadism in men, though the phenomenon is recognized across sexes. Its study is central to endocrinology and men's hormonal health.

What is the Mechanism of Androgenic Decline?

The decline stems from alterations in the hypothalamic-pituitary-gonadal (HPG) axis, leading to reduced testicular or adrenal gland output. Furthermore, age-related increases in Sex Hormone-Binding Globulin (SHBG) reduce the fraction of bioavailable free testosterone, limiting hormone action at the target cell receptor level. This cascade of events impairs androgenic signaling necessary for maintaining muscle mass, energy, and cognitive function.

Androgenic Decline

Meaning

Androgenic decline is the physiological process characterized by a gradual, age-associated reduction in the production and bioavailability of androgens, primarily testosterone and dehydroepiandrosterone (DHEA), in both males and females. This reduction often manifests clinically as diminished libido, decreased bone mineral density, and changes in body composition, including sarcopenia. It is a natural, yet variable, part of the aging endocrine landscape.