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Androgen Synthesis Timing

Meaning

Androgen Synthesis Timing is the chronobiological regulation of the endogenous production of androgens, primarily testosterone and dehydroepiandrosterone (DHEA), which follows a distinct circadian rhythm within the hypothalamic-pituitary-gonadal (HPG) axis. This physiological process is characterized by a peak synthesis and secretion typically occurring in the early morning hours, reflecting the pulsatile release pattern governed by the central nervous system. Understanding this natural timing is crucial for accurate diagnostic testing, which must account for the diurnal fluctuation, and for guiding the administration of exogenous therapeutic agents.