Clinical effects mediated by androgens on cutaneous tissue, often relating to sebum production, hair follicle cycling, and dermal matrix integrity. These benefits reflect the physiological role of androgens as anabolic agents influencing sebaceous gland function and follicular maturation. Understanding this balance is crucial in clinical dermatology and endocrinology for assessing skin health parameters.
Origin
The term derives from the Greek ‘andros’ meaning ‘man’ and ‘gen’ meaning ‘producer,’ reflecting the historical association with male sex hormones, though androgens are present and active in all sexes. In the context of skin, these effects originate from the binding of circulating androgens to specific nuclear receptors within the sebaceous glands and hair follicles. This signaling cascade initiates cellular responses that modulate epidermal differentiation and appendage development.
Mechanism
Androgen receptor activation in the pilosebaceous unit drives increased lipid synthesis and sebocyte proliferation, which is a key physiological function. Furthermore, androgens influence dermal fibroblast activity, potentially affecting collagen turnover and skin thickness, although the specific benefits are concentration-dependent and context-specific. The resulting physiological outcome supports skin barrier maintenance and sebaceous function in responsive tissues.
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