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Androgen Signaling Thresholds

Meaning

Androgen Signaling Thresholds represent the minimum concentration of androgens, such as testosterone or dihydrotestosterone, required at the cellular level to initiate a meaningful biological response within target tissues. These thresholds are not static; they vary across different tissues, including muscle, bone, and brain, and can be influenced by the density and sensitivity of the androgen receptors. Understanding and managing these thresholds is vital for optimizing the clinical efficacy of androgen replacement therapy and for assessing hormonal health.