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Androgen Signaling Restoration

Meaning

Androgen Signaling Restoration describes the targeted clinical effort to re-establish optimal responsiveness of target tissues to endogenous or exogenous androgens, such as testosterone and dihydrotestosterone. This process aims to normalize downstream effects crucial for muscle anabolism, bone density maintenance, and libido, irrespective of circulating total hormone levels. When signaling pathways are impaired, even adequate hormone concentrations may fail to elicit the desired physiological response, necessitating intervention at the receptor or post-receptor level. Our goal is functional efficacy, not merely circulating concentration normalization.