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Androgen Signaling Pathway Regulation

Meaning

This term describes the precise control mechanisms governing the actions of androgen hormones, such as testosterone and dihydrotestosterone (DHT), from their synthesis to their cellular effects. Regulation encompasses the dynamic control of androgen receptor expression, the activity of enzymes like 5-alpha reductase, and the feedback loops that maintain circulating hormone levels. Effective regulation is essential for maintaining muscle mass, bone density, libido, and mood in both males and females. Dysregulation in this pathway is clinically implicated in conditions like polycystic ovary syndrome (PCOS) and androgen-dependent cancers.