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Androgen Signaling Cascades

Meaning

Androgen signaling cascades represent the intricate intracellular molecular pathways initiated when androgen hormones, such as testosterone and dihydrotestosterone (DHT), bind to their specific receptors. This binding event triggers a sequence of protein-protein interactions and enzyme activations, ultimately leading to changes in gene expression within the cell nucleus. The resulting biological response dictates androgenic effects across various target tissues, influencing muscle mass, bone density, libido, and secondary sexual characteristics. Understanding this process is crucial for managing conditions related to androgen excess or deficiency in clinical endocrinology.