Question 1

What is the Meaning of Androgen-Sensitive Tissues?

Accepted Answer

Androgen-Sensitive Tissues are defined as specific bodily tissues and organs that express functional androgen receptors, rendering them responsive to the biological signals of androgens like testosterone and dihydrotestosterone (DHT). Key examples include the prostate gland, certain areas of the skin, hair follicles, and skeletal muscle. The precise health and morphological characteristics of these tissues are inextricably linked to the concentration and activity of circulating androgens.

Question 2

What is the Origin of Androgen-Sensitive Tissues?

Accepted Answer

This term is rooted in classical endocrinology, combining "androgen," which stems from the Greek words for "man" and "to produce," with the concept of "sensitive tissues" to denote target organ responsiveness. The sensitivity is biochemically determined by the presence and quantity of the intracellular androgen receptor protein. This physiological recognition established the foundation for understanding hormone-dependent growth and differentiation.

Question 3

What is the Mechanism of Androgen-Sensitive Tissues?

Accepted Answer

The primary mechanism involves lipid-soluble androgens diffusing across the cell membrane into the target cell cytoplasm. Once inside, the hormone binds to the androgen receptor, forming a complex that translocates into the nucleus. This hormone-receptor complex acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes. The resulting modification of gene transcription drives the tissue's specific physiological response, such as hair growth or prostate cell proliferation.

Androgen-Sensitive Tissues

Meaning

Origin

Mechanism

How Do 5-Alpha Reductase Inhibitors Affect Other Androgen-Sensitive Tissues beyond Hair?

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