What is the Origin of Androgen Sensitive Cell Response?

The concept originates from classical receptor pharmacology and molecular endocrinology, established when the mechanism of steroid hormone action was elucidated. Scientists determined that these lipophilic hormones cross the cell membrane and bind to intracellular receptors, triggering genomic effects. Understanding this cellular-level interaction is foundational to treating hormone-related disorders.

What is the Mechanism of Androgen Sensitive Cell Response?

Upon entering the target cell, the androgen binds to its cognate intracellular receptor, causing a conformational change in the receptor-hormone complex. This activated complex then translocates to the cell nucleus, where it binds to specific DNA sequences known as Androgen Response Elements (AREs). Binding to the AREs modulates the transcription of target genes, leading to the synthesis of new proteins that execute the androgen's physiological function.

Androgen Sensitive Cell Response ∞ Area

Androgen Sensitive Cell Response

Meaning

This term describes the specific physiological and biochemical changes that occur within cells possessing androgen receptors upon binding of an androgenic hormone, such as testosterone or dihydrotestosterone. The cellular response encompasses a cascade of events, including gene transcription modulation and protein synthesis, which ultimately drive male-typical characteristics and metabolic functions. The magnitude of this response is dictated by receptor density, receptor sensitivity, and the concentration of the free hormone.