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Androgen Saturation Theory

Meaning

The Androgen Saturation Theory posits that androgen receptors within target tissues, such as the prostate, become fully occupied or “saturated” at relatively low circulating levels of androgens like testosterone. Consequently, increasing systemic androgen concentrations beyond this saturation point may not lead to a proportional increase in the biological effect within that specific tissue. The theory suggests that tissue response is limited by receptor availability rather than the sheer quantity of circulating hormone once a threshold is met. Understanding this concept is critical for optimizing hormone replacement therapy while mitigating potential side effects in androgen-sensitive organs. Clinical practice often leverages this theory to guide dosing strategies and minimize risks associated with supraphysiological hormone levels.