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Androgen Saturation Model

Meaning

This is a conceptual framework describing the relationship between circulating androgen concentrations and the resulting biological effect mediated by the androgen receptor. It posits that beyond a certain physiological threshold, the androgen receptors in target tissues become maximally occupied or “saturated.” Consequently, further increases in free androgen levels do not lead to a proportionally greater biological response. This model helps explain why supraphysiological dosing may not yield greater clinical benefit but often increases adverse event risk.