Androgen Restoration Therapy is the clinical administration of androgens to restore physiological levels, typically in individuals experiencing androgen deficiency, to alleviate associated symptoms and improve health markers.
Context
This therapeutic approach operates within the endocrine system, specifically addressing the balance of hormones like testosterone and its metabolites, which are critical for numerous bodily functions in both males and females.
Significance
It holds importance for managing conditions such as hypogonadism, improving bone mineral density, enhancing muscle mass, boosting libido, and positively influencing mood and cognitive function, thereby enhancing overall quality of life.
Mechanism
The therapy involves supplementing endogenous androgen production through exogenous administration, typically via injections, transdermal applications, or oral formulations, to restore circulating hormone levels and their downstream effects.
Application
This therapy is prescribed following confirmed androgen deficiency identified through clinical evaluation and laboratory testing, with treatment plans individualized based on patient needs and response.
Metric
Treatment efficacy and safety are monitored through regular serum testing of total and free testosterone, sex hormone-binding globulin (SHBG), and clinical assessment of symptom resolution and potential adverse effects.
Risk
Potential risks include polycythemia, exacerbation of sleep apnea, adverse effects on the prostate, cardiovascular events, and mood disturbances, necessitating careful medical supervision and regular follow-up.
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