The clinical application of androgenic agents tailored to mimic endogenous production profiles, specifically addressing individual patient deficiencies. Precision involves achieving therapeutic serum concentrations that restore eugonadal function without inducing supraphysiological excursions or adverse receptor activity. This approach minimizes iatrogenic side effects while maximizing clinical benefits.
Origin
Combines “andros” (Greek for man) and “genesis” (Greek for creation) with the concept of replacement, originating from endocrinological treatment paradigms for hypogonadism. The addition of “precision” reflects modern pharmacodynamic goals.
Mechanism
This mechanism centers on careful dose titration and delivery route selection to control the absorption, distribution, metabolism, and excretion (ADME) of the administered androgen. Effective control ensures stable receptor binding across target tissues, optimizing outcomes in bone density, libido, and lean body mass accrual.
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