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Androgen Replacement Fidelity

Meaning

Androgen Replacement Fidelity denotes the clinical accuracy and consistency with which an exogenous androgen regimen replicates the body’s natural, physiological production and circulating levels of androgens. Achieving high fidelity involves maintaining stable serum concentrations of testosterone and its active metabolites, mirroring the natural diurnal rhythm where feasible, to optimize biological function. This concept extends beyond merely normalizing total levels, focusing instead on the precise biochemical environment necessary for optimal tissue signaling and overall endocrine health. It is a key metric for assessing the quality and success of a hormone replacement therapy program.