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Androgen Receptors in Brain

Meaning

Androgen receptors (AR) in the brain are intracellular proteins that bind to and mediate the effects of androgenic hormones, primarily testosterone and its potent metabolite, dihydrotestosterone (DHT). These receptors are widely distributed throughout various cerebral regions, including the hippocampus, hypothalamus, and cortex, indicating a broad neuroregulatory role. Their presence signifies a direct pathway through which androgens influence neuroendocrine function, mood regulation, cognitive performance, and neuroprotection. The function of these receptors is critical for maintaining central nervous system homeostasis across the lifespan in both males and females.