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Androgen Receptor Signaling

Meaning

This fundamental biological process describes the cascade of events initiated when androgen hormones, such as testosterone or dihydrotestosterone, bind to the intracellular Androgen Receptor (AR). The resulting complex translocates into the cell nucleus, where it directly interacts with DNA to modulate the transcription of specific genes. This signaling is critical for the development of male characteristics, maintaining muscle mass, bone density, and regulating libido in both sexes. Understanding this pathway is central to addressing conditions like androgen deficiency or prostate pathology.