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Androgen Receptor Saturation Model

Meaning

The Androgen Receptor Saturation Model is a pharmacological principle describing the relationship between the concentration of circulating androgens and the subsequent biological response mediated by the androgen receptor (AR). This model suggests that a point of diminishing returns is reached when the available androgen receptors in target tissues become maximally occupied, or saturated, by the hormone. Understanding this saturation limit is essential for optimizing therapeutic regimens like Testosterone Replacement Therapy (TRT) to achieve maximum symptomatic relief without exposing the patient to the risks associated with excessively high, supraphysiological hormone levels. The model provides a scientific basis for maintaining testosterone within a high-normal physiological range for optimal clinical efficacy.