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Androgen Receptor Crosstalk

Meaning

Androgen Receptor Crosstalk refers to the complex biochemical communication and mutual influence between the Androgen Receptor (AR) and other distinct cellular signaling pathways, such as those governed by growth factors or other steroid hormones. This intricate phenomenon allows non-androgenic signals to modulate the AR’s activity, impacting its ability to regulate gene expression and subsequent physiological effects in target tissues. Understanding this sophisticated interplay is critical for comprehending the full spectrum of androgen action and its clinical implications in health and disease.