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Androgen Receptor CAG Repeat

Meaning

This specific genetic marker refers to the variable number of cytosine-adenine-guanine (CAG) trinucleotide repeats found within the Androgen Receptor (AR) gene sequence. This intrinsic length dictates the potential functional efficiency of the AR protein once it is synthesized within the cell. In clinical endocrinology, variations here are significant as they correlate with differential tissue sensitivity to circulating androgens like testosterone. Understanding this polymorphism helps us contextualize individual responses to hormonal signaling pathways.