Skip to main content

Androgen Receptor Blockade

Meaning

Androgen receptor blockade is a therapeutic strategy employing pharmacological agents known as anti-androgens to inhibit the biological effects of androgens, such as testosterone and dihydrotestosterone (DHT), at the cellular level. This clinical intervention aims to mitigate the signaling cascade initiated when androgens bind to their cognate intracellular receptors. The blockade is utilized in managing various androgen-dependent conditions, including prostate cancer, hirsutism, and certain forms of acne. It is a precise method for achieving functional androgen withdrawal in specific target tissues without necessarily eliminating all circulating androgens.