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Androgen Receptor (AR) Sensitivity

Meaning

Androgen Receptor (AR) Sensitivity refers to the degree of cellular responsiveness to circulating androgen hormones like testosterone or dihydrotestosterone. High sensitivity means a robust biological response is generated even with lower hormone concentrations. Conversely, reduced sensitivity requires higher androgen levels to achieve the same cellular effect, impacting tissues such as muscle, bone, and hair follicles. Individual genetic variations and local tissue factors determine the functional responsiveness of these crucial nuclear receptors. This is fundamental to understanding hormonal balance and its clinical manifestations.