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Androgen Receptor Activation

Meaning

Androgen receptor activation is the critical process where androgen hormones, primarily testosterone and dihydrotestosterone (DHT), bind to their specific intracellular receptor protein. This binding event initiates a cascade of molecular changes, enabling the receptor-hormone complex to translocate into the cell nucleus. The successful activation of these receptors is fundamental for mediating all androgenic effects across various tissues, including muscle, bone, and skin. This process is the key determinant of a tissue’s anabolic response potential.