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Androgen Paradox

Meaning

The Androgen Paradox refers to the seemingly contradictory clinical observations regarding the role of androgens in certain physiological and pathological states, particularly in conditions like cardiovascular health or hair loss. For example, while androgens are essential for male cardiovascular integrity, excessively high or low levels can both be associated with increased risk factors. This term encapsulates the dual nature of androgen action, where the effect depends critically on concentration, tissue-specific metabolism, and receptor sensitivity. Clinicians must navigate this complexity in therapeutic dosing.