The clinical practice of intentionally adjusting the circulating concentrations of androgen hormones, such as testosterone and dihydrotestosterone (DHT), within the physiological range. This deliberate adjustment is typically performed to optimize specific health outcomes, address symptoms of deficiency or excess, and restore hormonal homeostasis. The process is guided by comprehensive diagnostic testing and patient-specific clinical presentation.
Origin
The concept stems from endocrinology, combining the Greek root “andro-” (man, male) and “-gen” (producing) for the hormone class, with the Latin “modulatio” (rhythm, measure) to describe the controlled adjustment of their serum levels. It belongs fundamentally to the clinical domain of hormonal replacement and optimization therapy.
Mechanism
Modulation involves manipulating the endocrine feedback loops, often targeting the hypothalamic-pituitary-gonadal (HPG) axis. Interventions can include administering exogenous hormones, utilizing selective receptor modulators, or employing agents that influence the enzymatic conversion or peripheral metabolism of androgens. The ultimate goal is to achieve stable, functional hormone concentrations that align with optimal health parameters.
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