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Androgen-Inflammation Axis

Meaning

The Androgen-Inflammation Axis describes the complex, bidirectional signaling pathway and regulatory loop existing between androgen hormones and the body’s systemic inflammatory response system. This axis highlights how androgens, such as testosterone and dihydrotestosterone, can modulate immune cell function and cytokine production, while inflammatory mediators, in turn, influence androgen synthesis and receptor sensitivity. Understanding this interaction is fundamental in conditions like polycystic ovary syndrome, prostate health issues, and age-related decline where hormonal and immune dysregulation often coexist. Clinical precision requires acknowledging this crosstalk when assessing chronic health states.