Question 1

What is the Meaning of Androgen Discontinuation?

Accepted Answer

Androgen Discontinuation refers to the deliberate cessation of therapeutic androgen administration, such as testosterone replacement therapy, in a patient. This clinical action may be necessitated by adverse effects, the achievement of therapeutic goals, or patient preference following a comprehensive risk-benefit analysis. A planned discontinuation protocol is vital to manage the potential physiological and psychological sequelae associated with the withdrawal of exogenous hormones. It is a critical phase requiring careful monitoring of the patient's endogenous hormonal recovery and symptom status.

Question 2

What is the Origin of Androgen Discontinuation?

Accepted Answer

This term is a construct from the clinical pharmacology and endocrinology domains, combining 'androgen,' referring to the class of steroid hormones, and 'discontinuation,' which denotes the act of stopping a medical treatment. The concept gains relevance specifically within the context of hormone replacement therapies where exogenous administration suppresses the body's native production. The practice of discontinuing androgens stems from the need to reverse suppression or mitigate long-term treatment risks.

Question 3

What is the Mechanism of Androgen Discontinuation?

Accepted Answer

Discontinuation initiates a period of hormonal flux as the body attempts to restart its native hypothalamic-pituitary-gonadal (HPG) axis, which was suppressed by the exogenous androgen. The immediate mechanism involves the clearance of the administered androgen from the system, leading to a rapid decline in circulating hormone levels. The pituitary gland then begins to increase the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), stimulating the testes to resume endogenous testosterone production. The time required for full HPG axis recovery is highly variable and depends on the duration and dose of prior therapy.

Androgen Discontinuation

Meaning

Origin

Mechanism

What Are the Physiological Mechanisms of Hormonal Discontinuation?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours