Androgen Deficiency Syndrome (ADS) is a clinical state characterized by consistently low levels of circulating androgens, such as testosterone and DHEA, accompanied by a constellation of specific, negative clinical signs and symptoms. This condition is not solely defined by a lab value but requires the presence of symptomatic manifestation impacting quality of life. Symptoms often include decreased libido, erectile dysfunction, reduced muscle mass, increased adiposity, and persistent fatigue.
Origin
The term “Androgen Deficiency Syndrome” emerged within the field of endocrinology to provide a more inclusive and accurate diagnostic framework for symptomatic androgen insufficiency, particularly in aging males, previously often termed “andropause.” It acknowledges the systemic impact of androgen insufficiency beyond reproductive function. The recognition of this syndrome underscores the critical role of androgens in metabolic, cognitive, and musculoskeletal health across the lifespan.
Mechanism
The underlying mechanism involves dysfunction at various levels of the hypothalamic-pituitary-gonadal (HPG) axis, leading to insufficient androgen production by the testes or adrenal glands. Primary deficiency results from testicular failure, while secondary deficiency stems from impaired signaling from the hypothalamus or pituitary. This deficiency results in inadequate activation of androgen receptors in target tissues, disrupting downstream processes responsible for maintaining muscle protein synthesis, bone density, and sexual function.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.