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Androgen Clearance Pathways

Meaning

The Androgen Clearance Pathways refer to the essential biochemical routes the body utilizes to metabolize and eliminate androgen hormones, such as testosterone and dihydrotestosterone, from systemic circulation. This complex process primarily occurs in the liver, involving a series of enzymatic reactions that convert active, lipophilic steroids into inactive, water-soluble compounds. Effective clearance is critical for maintaining hormonal homeostasis and preventing the accumulation of metabolites that could exert unwanted biological effects. Clinical evaluation of these pathways helps assess the body’s capacity to process and balance these potent hormones.