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Anastrozole Mechanism in HRT

Meaning

Anastrozole is a pharmaceutical agent classified as a non-steroidal aromatase inhibitor, clinically utilized within Hormone Replacement Therapy (HRT) protocols, primarily in males, to manage estrogenic side effects. This compound serves to modulate the conversion of endogenous or exogenous androgens, such as testosterone, into estradiol. Its incorporation is a strategic intervention aimed at maintaining an optimal testosterone-to-estradiol ratio, preventing potential adverse effects associated with elevated estrogen levels. Careful clinical titration ensures the benefits of androgen optimization are realized without inducing estrogen deficiency symptoms.