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Anabolic Threshold Elevation

Meaning

Anabolic threshold elevation describes a state in which a higher concentration or stimulus of anabolic factors, such as specific amino acids or resistance exercise, is required to initiate a measurable increase in protein synthesis or tissue growth. This physiological phenomenon is frequently observed in aging individuals or those with chronic metabolic dysfunction, signifying a degree of anabolic resistance in target tissues like skeletal muscle. Addressing this elevation is a core clinical goal in longevity medicine, focusing on nutritional and hormonal strategies to restore tissue responsiveness. It reflects a diminished sensitivity of cellular machinery to growth signals, impeding optimal repair and maintenance.