Skip to main content

Anabolic Signaling Downregulation

Meaning

Anabolic Signaling Downregulation describes a clinically observed reduction in the intensity or responsiveness of cellular pathways responsible for growth, repair, and tissue synthesis. This phenomenon is a hallmark of sarcopenia and metabolic aging, indicating a reduced capacity for muscle protein synthesis and tissue maintenance. It manifests as a diminished biological response to anabolic stimuli like resistance exercise, adequate protein intake, or specific growth factors and hormones. Recognizing this downregulation is essential for tailoring effective restorative therapies.